Sunday, March 31, 2013

Elite 8 Begins With Big East Matchup And Cinderella Story On Saturday

The Elite Eight features lottery picks, blue bloods and fittingly, a Cinderella not quite ready to go home. Syracuse's Michael Carter-Williams and Ohio State's Deshaun Thomas might be the two best players left in the field not named Trey Burke, yet neither is featured in my key matchups today.

Here are the two matchups to watch on Saturday.

Marquette's Davante Gardner vs. Syracuse Bigs

Naturally, Syracuse point guard Michael Carter-Williams is a budding star at point guard, but the battle of the bigs will determine this game. Marquette's Davante Gardner is a load in the paint with surprisingly deft feet for such a big body, but the 'Cuse offers an extreme dose of length. Baye Keita and C.J. Fair are both awesome athletes and talented shot blockers, but Gardner got the best of them in late February. when the 6-foot-8 junior went 7-7 and scored a career-high 26 points.

Speaking of the Syracuse Orangemen -- who lost 74-71 in the teams' only meeting this season -- we turn to the vaunted 2-3 matchup zone, which stymied a super talented Indiana team and kept it to just 50 points, 30 below its season average. As a whole, Marquette's Golden Eagles aren't prolific from a distance, but if you don't at least make a couple early, that zone becomes awfully active.

Wichita State PG Malcolm Armstead vs. Ohio State PG Aaron Craft

Ohio State's Aaron Craft is the best on-ball defender in America alongside Indiana's Victor Oladipo, although he struggled to contain Arizona's Mark Lyons in the half-court. Wichita State's Malcolm Armstead is an elite playmaker whose somewhat awkward lefty game can be extremely tricky to defend.

Wichita State hasn't been to a Final Four since 1965 (its only appearance in program history), but has already defeated Pittsburgh and top seed Gonzaga. Ohio State meanwhile, has posted 11 consecutive victories and has a tremendous toughness about it that Craft fuels. One of the great things about the junior point guard is how well he contains dribble penetration, which is the key to Armstead's scoring ability, because he's such a special finisher in the lane. The Wichita State Shockers are a carbon copy of a classic Big Ten team because of how well they defend in the half-court and how physically they play, but Armstead has to have a 20-plus night in order to spring the upset.

Email me at jordan.schultz@huffingtonpost.com or ask me questions about anything sports-related at @Schultz_Report.

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Source: http://www.huffingtonpost.com/2013/03/30/elite-8-saturday_n_2982449.html

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Snooki Gives Kim Kardashian Advice For Giving Birth In Style (VIDEO)

We wouldn't recommend taking advice from Snooki when it comes to, well, most things. But when the erstwhile "Jersey Shore" star decided to offer up some words of wisdom to Kim Kardashian, we were more than willing to eavesdrop -- out of sheer curiosity, of course.

Addressing the pregnant star in her capacity as Celebrity Baby Correspondent for Celebuzz (looks like she's found a second career?), Snooki dishes about "how to look glam during labor -- because it's a bitch."

"If your face isn't already made up when your water breaks," new mom Snooki says in the Celebuzz video, "you have plenty of time to do it in the hospital when you're waiting to dilate." Yippee! Just make sure to choose your color palette wisely, she says, seeing as hospital lighting and decor is totally drab.

The new mom also tells Kim to be prepared in case of emergencies: "Remember to keep an extra pair of eyelashes in your purse just in case your water breaks when you're not at home. Or just do like I did and bring a whole box."

And on the subject of jewelry: "Make sure you stay away from the big hoop earrings, because it can get caught in your extensions. But you can wear some nice diamond studs so you look really cute in your selfies."

Oh, how well she knows Kim.

Think we're making any of this up? Believe it, baby -- or just watch the Celebuzz video below and see for yourself.

WATCH:

See how Kim's gone glam since getting pregnant:

  • March 17, Atlanta, Georgia

  • March 16

  • March 11, Los Angeles

  • March 3, Paris

  • February 27, Los Angeles

  • February 22, Los Angeles

  • February 16, Los Angeles

  • February 14

  • January 14, JFK Airport

  • January 13, Calabasas

  • January 6, Miami

    Hey, sexy lady.

  • January 6, Calgary

  • January 31, Las Vegas

    Proving that pregnancy doesn't mean ya can't go sheer.

  • Kim Kardashian, December 14th

    Looking comfy (as far as Kardashian Klothes go) in a slouchy tee and skinny jeans

  • December 6, Miami Heat game

    Going laid-back in a white button-down shirt and black pants. We like!

  • December 2, Miami International Airport

    Another slouchy tee, this time with drawstring pants and a blazer.

  • December 1, Bahrain

    Kate Middleton's jewel-toned shift, filtered through the Kardashian lens.

  • November 29, Kuwait City

    A bodycon dress with cap toe stilettos. Not exactly the outfit that would invite the tabloids to start a bump watch, no?

  • November 19, Miami

  • November 11, Frankfurt

    A simple v-neck long-sleeve top and a mullet skirt. Business in the front, party in the back?

  • November 10, London

    With sisters Kourtney and Khloe, wearing a simple black dress with a statement belt.

  • November 9, London

    Only Kimmy K. can wear boob cutouts while pregnant.

  • November 9, London

    Doing the jumpsuit thang.

  • November 8, London

    With sister Kourtney (and Kourt's many polka dots), wearing liquid sequins.

  • November 8, London

    Shine on, Kim.

  • October 27, New York

    As a mermaid in rhinestones, pearls and layers of stretch fabric.

  • October 22, New York

    Another vaguely Kate Middleton-esque dress (think: jewel tone, flowy) but also distinctly Kimye in its own way.

  • Kanye West Makes Pregnancy Announcement at a Concert in Atlantic City

    Rapper Kanye West has announced he and his girlfriend, reality show star Kim Kardashian, are expecting their first child together. He stopped mid-performance at a concert in Atlantic City on Sunday to ask the crowd to make some noise for his baby mama, and then continued where he'd left off. The news has been confirmed by members of the Kardashian family both by Twitter and through US network E!, who host their reality television shows.

Want more? Be sure to check out HuffPost Style on Twitter, Facebook, Tumblr, Pinterest and Instagram at @HuffPostStyle.
--
Do you have a style story idea or tip? Email us at stylesubmissions@huffingtonpost.com. (PR pitches sent to this address will be ignored.)

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Source: http://www.huffingtonpost.com/2013/03/30/snooki-kim-kardashian-advice_n_2986246.html

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Saturday, March 30, 2013

Rogue ex-cop's victim makes 1st public appearance

RIVERSIDE, Calif. (AP) ? A Riverside police officer nearly killed in an ambush by rogue ex-cop Christopher Dorner made his first public appearance since the shooting, at an emotional dinner where he was greeted warmly by friends and admirers and shared a table with the wife of his late training officer.

Officer Andrew Tachias was sitting in his patrol car with Officer Michael Crain on Feb. 7 when Dorner pulled alongside them at a stoplight and opened fire.

Crain was killed. Tachias, who is still recovering, was shot eight times.

"I think he's like all of us. It's ups and downs," Crain's widow, Regina, said of Tachias. "One minute you're fine, and the next you are in a hole."

She added the dinner was the first time she and Tachias, 27, had met.

The officer, whose wounded hands were encased in protective coverings, has said he wants to return to work.

"I'm absolutely speechless for him to be back in this environment," said Officer Scott Levesque, who was among those at the event at Riverside's Original Roadhouse Grill.

The dinner capped a daylong fundraiser for the families of Tachias and Crain. It drew so many people that at one point, the restaurant ran out of silverware, the Riverside Press-Enterprise reported (http://bit.ly/X4bhPe).

Tachias, dressed in a gray and black striped hoodie and sporting a beard, was greeted with hugs when he arrived at about 8 p.m. and took a table with Crain's widow.

"To be close to the person who was with him last is comforting to me," Regina Crain said.

Crain's father also attended the event, along with Riverside Police Chief Sergio Diaz and Lt. Larry Gonzalez, the watch commander on duty when Crain and Tachias were attacked.

Dorner went on a rampage after he was fired by the Los Angeles Police Department for filing a false report.

He killed four people and wounded Tachias before committing suicide Feb. 12 after he was cornered in a mountain cabin near Big Bear Lake.

Authorities surrounded the cabin after a wild chase that began when Dorner tied up a couple and stole their car, crashed it and carjacked another vehicle at gunpoint, then crashed that one and fled to the cabin.

Source: http://news.yahoo.com/rogue-ex-cops-victim-makes-1st-public-appearance-183202187.html

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PFT: Raiders close to Flynn trade, cutting Palmer

Troy PolamaluAP

Sometimes, wishes are quickly granted.? Sometimes, they already were.

Steelers safety Troy Polamalu wants player input in rule changes.? But the players already have input.

?I do wish . . . that the NFL did have a voice from the players? side, whether it?s our players? union president, or team captains, or our executive committee on the players? side,? Polamalu said earlier today on ESPN.? ?Because we?re the guys that realize the risk, we?re the guys on the field.?

As MDS pointed out, the players have a voice in the rule-revising process.? Specifically, this year?s the rule changes were discussed with NFLPA president Domonique Foxworth, who worked with Lester Archambeaux, Charlie Batch, Ernie Conwell, Matt Hasselbeck, Brandon Moore, Jeff Saturday, Ben Watson, and Eric Winston in providing input to the Competition Committee.

Also, Will Montgomery of the Redskins presented video to the Competition Committee in connection with the rule that makes the snapper a defenseless player.

Former players also had a voice with the Player Safety Advisory panel, which includes John Madden, Ronnie Lott, Ernie Accorsi, Antonio Freeman, Patrick Kerney, Willie Lanier, Oliver Luck, Steve Mariucci, Anthony Munoz.

So, basically, Polamalu already got what he wanted, without finding a lamp or losing an eyelash.

Source: http://profootballtalk.nbcsports.com/2013/03/29/raiders-appear-close-to-adding-matt-flynn-cutting-carson-palmer/related/

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Friday, March 29, 2013

Barbara Walters Retirement: Coming in 2014?

Source: http://www.thehollywoodgossip.com/2013/03/barbara-walters-retirement-coming-in-2014/

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China: Landslide traps 83 in Tibet gold mine area

BEIJING (AP) ? Chinese state media say a large landslide Friday trapped 83 workers in a gold mining area in Tibet.

China Central Television cited a local official as saying the landslide occurred early in the morning and covered around 4 square kilometers (1.5 square miles) in the Maizhokunggar county of Lhasa, the regional capital.

The official Xinhua News Agency said the workers were from a subsidiary of the China National Gold Group Corp.

The reports said the landslide was caused by a "natural disaster" but did not provide specifics. It was unclear why the first news reports of the landslide came out several hours after it occurred.

Rescue efforts were under way Friday night, the reports said.

County officials reached by phone confirmed the landslide but had no further details. Calls to the company's general phone line rang unanswered.

Doctors reached at the local county hospital said they had been told to prepare to receive survivors but none had arrived. "We were ordered to make all efforts to receive the injured," said a doctor who gave only her surname, Ge, in the hospital's emergency section.

Ge said the hospital transferred some of its patients to other facilities to increase the number of beds available and that 16 doctors were on duty.

Source: http://news.yahoo.com/china-landslide-traps-83-tibet-gold-mine-area-144134758.html

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Excerpts of gay marriage cases at high court

Excerpts from arguments before the Supreme Court on Wednesday about a federal law that prevents legally married gay couples from receiving a range of benefits afforded straight married Americans, from a transcript released by the Supreme Court:

___

On why President Barack Obama is still enforcing the law if he believes it is unconstitutional (Chief Justice John Roberts):

ROBERTS: If (President Obama) has made a determination that executing the law by enforcing the terms is unconstitutional, I don't see why he doesn't have the courage of his convictions and execute not only the statute, but do it consistent with his view of the Constitution, rather than saying, oh, we'll wait till the Supreme Court tells us we have no choice.

___

On the question of whether the definition of marriage should be a federal matter (Justice Anthony Kennedy and Paul Clement, the lawyer representing the House Republican leadership in defending the law):

KENNEDY: But when it has 1,100 laws, which in our society means that the federal government is intertwined with the citizens' day-to-day life, you are at ? at real risk of running in conflict with what has always been thought to be the essence of the state police power, which is to regulate marriage, divorce, custody.

CLEMENT: Well, Justice Kennedy, two points. First of all, the very fact that there are 1,100 provisions of federal law that define the terms "marriage" and "spouse" goes a long way to showing that federal law has not just stayed completely out of these issues. It's gotten involved in them in a variety of contexts where there is an independent federal power that supported that. Now, the second thing is the fact that (the Defense of Marriage Act) involves all 1,100 statutes at once is not really a sign of its irrationality. It is a sign that what it is, and all it has ever purported to be, is a definitional provision. And like every other provision in the Dictionary Act, what it does is it defines the term wherever it appears in federal law in a consistent way. And that was part and parcel of what Congress was trying to accomplish with DOMA in 1996.

___

On the issue of benefits (Justice Ruth Bader Ginsburg and Clement):

GINSBURG: They're not ? they're not a question of additional benefits. I mean, they touch every aspect of life. Your partner is sick. Social Security. I mean, it's pervasive. It's not as though, well, there's this little federal sphere and it's only a tax question. It's ? it's ? as Justice Kennedy said, 1,100 statutes, and it affects every area of life. And so he was really diminishing what the state has said is marriage. You're saying, no, state said two kinds of marriage; the full marriage, and then this sort of skim milk marriage.

(Laughter.)

CLEMENT: With respect, Justice Ginsburg, that's not what the federal government is saying. The federal government is saying that within its own realm in federal policies, where we assume that the federal government has the authority to define the terms that appear in their own statute, that in those areas, they are going to have their own definition.

___

On what Congress intended when it passed the bill in 1996: (Justice Elena Kagan and Clement):

KAGAN: Well, is what happened in 1996 ? and I'm going to quote from the House Report here ? is that "Congress decided to reflect an honor of collective moral judgment and to express moral disapproval of homosexuality." Is that what happened in 1996?

CLEMENT: Does the House Report say that? Of course, the House Report says that. And if that's enough to invalidate the statute, then you should invalidate the statute. But that has never been your approach, especially under rational basis or even rational basis-plus, if that is what you are suggesting. This Court, even when it's to find more heightened scrutiny, the O'Brien case we cite, it suggests, look, we are not going to strike down a statute just because a couple of legislators may have had an improper motive. We're going to look, and under rational basis, we look: Is there any rational basis for the statute? And so, sure, the House Report says some things that we are not ? we've never invoked in trying to defend the statute. But the House Report says other things, like Congress was trying to promote democratic self-governance.

___

On whether there has been a "sea change" in opinion on gay marriage since the law was enacted in 1996 (Roberta Kaplan, the lawyer for the 83-year-old New York woman who sued over DOMA, and Justice Antonin Scalia):

KAPLAN: I think (the 1996 law) was based on an understanding that gay ? an incorrect understanding that gay couples were fundamentally different than straight couples, an understanding that I don't think exists today and that's the sense I'm using that times can blind. I think there was ? we all can understand that people have moved on this, and now understand that there is no such distinction. So I'm not saying it was animus or bigotry, I think it was based on a misunderstanding on gay people and their ?

SCALIA: Why ? why are you so confident in that ? in that judgment? How many ? how many states permit gay ? gay couples to marry?

KAPLAN: Today? 9, Your Honor.

SCALIA: 9. And -- and so there has been this sea change between now and 1996.

KAPLAN: I think with respect to the understanding of gay people and their relationships there has been a sea change, Your Honor.

___

On recent declarations by several lawmakers that they are switching their positions on gay marriage (Roberts and Kaplan):

ROBERTS: As far as I can tell, political figures are falling over themselves to endorse your side of the case.

KAPLAN: The fact of the matter is, Mr. Chief Justice, is that no other group in recent history has been subjected to popular referenda to take away rights that have already been given or exclude those rights, the way gay people have.

___

On Tuesday, a day earlier, the court considered California's ban on same-sex marriage. Excerpts from those arguments:

___

On whether the case should be before them (Chief Justice John Roberts and Justice Anthony Kennedy):

ROBERTS: But a state can't authorize anyone to proceed in federal court, because that would leave the definition under Article III of the federal Constitution as to who can bring ? who has standing to bring claims up to each state. And I don't think we've ever allowed anything like that.

KENNEDY: The problem ? the problem with the case is that you're really asking, particularly because of the sociological evidence you cite, for us to go into uncharted waters, and you can play with that metaphor, there's a wonderful destination, it is a cliff. Whatever that was. ... But you're ? you're doing so in a ? in a case where the opinion is very narrow. Basically that once the state goes halfway, it has to go all the way or 70 percent of the way, and you're doing so in a case where there's a substantial question on ? on standing. I just wonder if ? if the case was properly granted.

___

On the question of children of same-sex parents (Kennedy and Charles Cooper, lawyer for the defenders of Proposition 8):

KENNEDY: I think there's ? there's substantial ? that there's substance to the point that sociological information is new. We have five years of information to weigh against 2,000 years of history or more. On the other hand, there is an immediate legal injury or legal ? what could be a legal injury, and that's the voice of these children. There are some 40,000 children in California, according to the red brief, that live with same-sex parents, and they want their parents to have full recognition and full status. The voice of those children is important in this case, don't you think?

COOPER (in response): I certainly would not dispute the importance of that consideration. That consideration especially in the political process, where this issue is being debated and will continue to be debated, certainly, in California. It's being debated elsewhere. But on that ? on that specific question, Your Honor, there simply is no data.

___

On the issue of same-sex marriage (Justice Samuel Alito):

ALITO: The one thing that the parties in this case seem to agree on is that marriage is very important. It's thought to be a fundamental building block of society and its preservation essential for the preservation of society. Traditional marriage has been around for thousands of years. Same-sex marriage is very new. I think it was first adopted in The Netherlands in 2000. So there isn't a lot of data about its effect. And it may turn out to be a ? a good thing; it may turn out not to be a good thing, as the supporters of Proposition 8 apparently believe.

___

On the question of redefining marriage (Justice Antonin Scalia):

SCALIA: Mr. Cooper, let me ? let me give you one ? one concrete thing. I don't know why you don't mention some concrete things. If you redefine marriage to include same-sex couples, you must ? you must permit adoption by same-sex couples, and there's ? there's considerable disagreement among ? among sociologists as to what the consequences of raising a child in a ? in a single-sex family, whether that is harmful to the child or not. Some states do not ? do not permit adoption by same-sex couples for that reason.

___

On the rights of same-sex couples (Theodore Olson, lawyer for two same-sex couples, and Roberts):

OLSON: This is a measure that walls off the institution of marriage, which is not society's right. It's an individual right that this Court again and again and again has said the right to get married, the right to have the relationship of marriage is a personal right. It's a part of the right of privacy, association, liberty, and the pursuit of happiness.

ROBERTS (in response): I'm not sure, counsel, that it makes ? I'm not sure that it's right to view this as excluding a particular group. When the institution of marriage developed historically, people didn't get around and say let's have this institution, but let's keep out homosexuals. The institution developed to serve purposes that, by their nature, didn't include homosexual couples. It is ? yes, you can say that it serves some of the other interests where it makes sense to include them, but not all the interests. And it seems to me, your friend argues on the other side, if you have an institution that pursues additional interests, you don't have to include everybody just because some other aspects of it can be applied to them.

___

On the Constitution and same-sex couples (Olson and Scalia):

SCALIA: The California Supreme Court decides what the law is. That's what we decide, right? We don't prescribe law for the future. We decide what the law is. I'm curious, when ? when did -- when did it become unconstitutional to exclude homosexual couples from marriage? 1791? 1868, when the Fourteenth Amendment was adopted? Sometimes ? some time after Baker, where we said it didn't even raise a substantial Federal question? When ? when ? when did the law become this?

OLSON: May I answer this in the form of a rhetorical question? When did it become unconstitutional to prohibit interracial marriages? When did it become unconstitutional to assign children to separate schools?

SCALIA: It's an easy question, I think, for that one. At ? at the time that the Equal Protection Clause was adopted. That's absolutely true. But don't give me a question to my question. (laughter) ... When do you think it became unconstitutional? Has it always been unconstitutional?

OLSON: When the California Supreme Court faced the decision, which it had never faced before, is ? does excluding gay and lesbian citizens, who are a class based upon their status as homosexuals ? is it ? is it constitutional.

___

On sexual orientation (Justice Sonia Sotomayor and Cooper):

SOTOMAYOR: Outside of the marriage context, can you think of any other rational basis, reason, for a state using sexual orientation as a factor in denying homosexuals benefits or imposing burdens on them? Is there any other rational decision-making that the government could make? Denying them a job, not granting them benefits of some sort, any other decision?

COOPER (in response): I cannot. I do not have any ? anything to offer you in that regard. ... We are saying the interest in marriage and the ? and the state's interest and society's interest in what we have framed as responsible procreation is ? is vital, but at bottom, with respect to those interests, our submission is that same-sex couples and opposite-sex couples are simply not similarly situated.

___

On procreation and age (Justice Elena Kagan and Cooper, and later Scalia):

KAGAN: If you are over the age of 55, you don't help us serve the government's interest in regulating procreation through marriage. So why is that different?

COOPER: Even with respect to couples over the age of 55, it is very rare that both couples ? both parties to the couple are infertile, and the traditional ? (laughter.)

KAGAN: No, really, because if the couple ? I can just assure you, if both the woman and the man are over the age of 55, there are not a lot of children coming out of that marriage. (laughter)

COOPER: Society's interest in responsible procreation isn't just with respect to the procreative capacities of the couple itself. The marital norm, which imposes the obligations of fidelity and monogamy, Your Honor, advances the interests in responsible procreation by making it more likely that neither party, including the fertile party to that ?

KAGAN: Actually, I'm not even ?

SCALIA: I suppose we could have a questionnaire at the marriage desk when people come in to get the marriage ? you know, Are you fertile or are you not fertile? (laughter) I suspect this court would hold that to be an unconstitutional invasion of privacy, don't you think?

KAGAN: Well, I just asked about age. I didn't ask about anything else. That's not ? we ask about people's age all the time.

COOPER: Your Honor, and even asking about age, you would have to ask if both parties are infertile. Again --

SCALIA: Strom Thurmond was ? was not the chairman of the Senate committee when Justice Kagan was confirmed. (laughter)

_____

Online - Tuesday arguments: http://tinyurl.com/dxefy2a

Online - Wednesday arguments: http://tinyurl.com/d626ybg

Source: http://news.yahoo.com/excerpts-gay-marriage-cases-high-court-002503953.html

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Thursday, March 28, 2013

Falcons agree to 2-year deal with Osi Umenyiora

ATLANTA (AP) ? The Atlanta Falcons found a replacement for John Abraham on Wednesday by reaching an agreement with free-agent defensive end Osi Umenyiora on a two-year, $8.5 million contract.

The Falcons released the 34-year-old Abraham, the team leader with 10 sacks in 2012, on March 1, the same day they also released running back Michael Turner and cornerback Dunta Robinson.

The team replaced Turner by signing Steven Jackson to a three-year, $12 million deal March 14. Now Umenyiora joins Jackson as Atlanta's second major free-agent addition.

The Falcons scheduled a news conference with Umenyiora for Thursday.

The 31-year-old Umenyiora gives the Falcons a slightly younger replacement at defensive end, but his production has declined in recent years. He had only six sacks for the Giants in 2012, when he started only four of 16 games. He had 55 tackles, five for losses, and one forced fumble.

He had a career-high 14? sacks in 2005, when he was a first-team All-Pro selection. He has reached double figures in sacks only one of the last four years ? 11? in 2010.

Umenyiora, 6-foot 3 and 255 pounds, was a second-round pick from Troy State by New York in 2003. He has 75 sacks, 31 forced fumbles and 13 fumble recoveries in his career and helped the Giants win two Super Bowl championships.

He set an NFL record with 10 forced fumbles in 2010 and a Giants record with six sacks in a 2007 win over Philadelphia.

The presence of defensive ends Jason Pierre-Paul and Justin Tuck made Umenyiora a part-time starter last season, but he'll be expected to replace Abraham as the Falcons' top pass-rusher. Defensive end Kroy Biermann was second on the Falcons with only 4 sacks last season.

Umenyiora's agent, Tom Condon, couldn't be immediately reached for comment.

Umenyiora made a brief reference to his new NFL home on his Twitter feed when he tweeted "(hash)RISE UP" ? the Falcons' slogan.

Source: http://news.yahoo.com/falcons-agree-2-deal-osi-umenyiora-015236611--nfl.html

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Child With Hearing Disorder Gets Wish

Mar 26, 2013 11:14pm

ABC News? Dan Harris, Julia Bain and Dr. Mark Abdelmalek report:

You would have to look closely, but if you kept your eye on Carson Rubin, you would see he is consistently one step behind his preschool classmates.

Carson claps only after seeing everyone else doing it, sits for a few more seconds when all the other kids stand up, and stares off when teachers are talking to him.

?I think he?s constantly trying to keep up,? Shay Rubin, Carson?s mother, told ABC News. ?I think he wears himself out trying to keep up with everybody else, and trying to figure out what?s going on all the time.?

Carson is 5 years old and has a condition called auditory neuropathy, a hearing and nerve disorder where sound waves entering the ear can?t reach the right parts of the brain.

For Carson, the world around him sounds like a radio station that?s not quite tuned in.

?You hear a sound, but it?s not very clear,? Lauren Stott, Carson?s audiologist said. ?It?s distorted or static. You feel like, ah, I can tell there?s something there but it?s not quite right.?

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Image credit: ABC News

Carson?s parents worry his condition is not only damaging his intellectual development, but also endangers his safety.

If there was a car coming fast down a street, he wouldn?t hear it.

The good news is that there is a treatment that could dramatically improve Carson?s hearing called cochlear implants.

Karen Munoz, associate professor of audiology at Utah State University, who is not involved with Carson?s case, said: ?Cochlear implants will open his world to sound and the ability to fully engage in the world around him.?

Cochlear implants involve a surgery that has produced miraculous results for many children. But at a cost as high as $132,000 per ear, individuals would either?need to have $264,000 on hand, or an insurance policy that covers the procedure.

The bad news is that when the Rubin?s first asked their insurance plan, Coventry Health Care of Georgia, they were told their policy didn?t cover cochlear implants.

The exclusion for cochlear implants is listed on the Coventry Health Care of Georgia plan documents provided to the Rubins.

?Without appropriate access to hearing the skill to develop spoken language won?t occur,? said Munoz.

For Carson to get the surgery the Rubins were daunted by the idea they may have to set?up a payment plan to get their son the treatment he needed to hear.

When ABC News? first contacted Coventry Health Care of Georgia, Coventry issued the following statement:

?Coventry is committed to offering affordable coverage and access to high quality care to all of our members.?While Coventry?s policies provide coverage for a broad scope of benefits and services,?no health?insurance?policy?covers?every?procedure. ?Currently, states determine which benefits and services must be covered, and Coventry?s policies always comply with state requirements. Consistent with the standards for Georgia?s small group market and state regulations, Coventry?s small group policies have not covered cochlear implants.?

As many as 90 percent of private insurance companies and all Medicaid programs cover cochlear implants.

A 2008 Vanderbilt study estimated that 12,816 children would be considered for cochlear implants each year.? And every year more than 1,000 kids who are candidates are likely to be denied cochlear implants by their private insurance companies.

In 2011, Coventry earned roughly half a billion dollars in profit. Allen Wise, Coventry?s CEO, is number 53 on the Forbes list of richest executives, and in 2011 had a total compensation package of $20.87 million, which could cover Carson?s implants 80 times over.

?We?re just an American family trying to raise children and have a family and this is the predicament we find ourselves in,? Brian Rubin said.

Brian Rubin and Shay Rubin, a stay-at-home mom, live in suburban Atlanta, with their two children. At first, the parents turned to Facebook to raise money for their son?s cochlear implants, raising nearly $10,000, a drop in the bucket for a procedure.

Despite the setbacks, the Rubins remained determined.

?One way or another he?s going to get what he needs,? said Shay.

Coventry Health Care denied ABC News? repeated requests for an on-camera interview, but when ABC News made one last call to Coventry we learned they had changed their position on covering cochlear implants.

Coventry issued the following statement to ABC News on the matter:

?Until very recently, small group policies in Georgia have not covered cochlear implants, and?Coventry?s policies remained consistent with those standards. We understand policies have shifted, and as a result, we are making a similar change to our policies.?Coventry?Health Care of Georgia will cover cochlear implants for commercial members as of April 1.?

Carson Rubin?s cochlear implant surgery is scheduled on April 19.

This change in policy is only for members of Coventry Health Care in Georgia. ? But while Coventry Health Care operates plans in 25 states, cochlear implants are only covered for their members in Utah and now Georgia.

When asked if Coventry Health Care would change its cochlear implant coverage policy for its other 23 states, they told ABC News, ?We are?re-evaluating?our policies in other states.?

But coverage for hearing devices and specifically cochlear implants may improve with the Affordable Care Act, possibly as early as 2014.

Janet McCarty, the private health plans?adviser?at the American Speech-Language Hearing Association and a member of the organization?s Government Relations and Public Policy Committee told ABC News, ?Under the Affordable Care Act, as one of the essential benefits, there are rehabilitation and habilitation services that?theoretically?would cover health care services that would help a person keep, learn or improve skills or?functions?of daily living.? ?McCarty hopes hearing aids and speech generating devices like cochlear implants would be covered under the Affordable Care Act.

The Rubins? prayers were answered and when they heard Coventry had changed their policy to cover Carson?s cochlear implants, the shock was almost too much.

?I kind of couldn?t breathe for awhile,? Shay Rubin said.

Source: http://abcnews.go.com/blogs/health/2013/03/26/child-who-needs-corrective-hearing-surgery-gets-wish/

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Gun control backers struggle to win some Democrats

FILE - In this Jan. 21, 2013 photo, Emma Clyman, 5, of Manhattan, holds a sign that reads "No More Newtowns" outside city hall park during the One Million Moms for Gun Control Rally in New York. Despite a proposal backed by over 8 in 10 people in polls, gun control supporters are struggling to win over moderate Democrats in their drive to push expanded background checks of firearms purchasers through the Senate next month. (AP Photo/John Minchillo, File)

FILE - In this Jan. 21, 2013 photo, Emma Clyman, 5, of Manhattan, holds a sign that reads "No More Newtowns" outside city hall park during the One Million Moms for Gun Control Rally in New York. Despite a proposal backed by over 8 in 10 people in polls, gun control supporters are struggling to win over moderate Democrats in their drive to push expanded background checks of firearms purchasers through the Senate next month. (AP Photo/John Minchillo, File)

FILE - In this May 19, 2011 file photo, Chairman Mark Pryor, D-Ark., speaks during a hearing of the Subcommittee on Consumer Protection, Product Safety, and Insurance on cell phone privacy on Capitol Hill in Washington. Despite a proposal backed by over 8 in 10 people in polls, gun control supporters are struggling to win over moderate Democrats like Pryor in their drive to push expanded background checks of firearms purchasers through the Senate next month. (AP Photo/Alex Brandon, File)

FILE - In this Nov. 6, 2012 file photo, Sen.-elect Heidi Heitkamp, D-N.D., address her supporters in Bismarck, N.D. Despite a proposal backed by over 8 in 10 people in polls, gun control supporters are struggling to win over moderate Democrats like Heitkamp in their drive to push expanded background checks of firearms purchasers through the Senate next month. (AP Photo/Will Kincaid, File)

(AP) ? It would seem a lobbyist's dream: rounding up votes for a proposal backed by more than 8 in 10 people in polls. Yet gun control supporters are struggling to win over moderate Democrats in their drive to push expanded background checks for firearms purchasers through the Senate next month.

Backed by a $12 million TV advertising campaign financed by New York Mayor Michael Bloomberg, gun control groups scheduled rallies around the country Thursday aimed at pressuring senators to back the effort. President Barack Obama was meeting at the White House with gun violence victims.

Moderate Senate Democrats like Mark Pryor of Arkansas and Heidi Heitkamp of North Dakota are shunning Bloomberg as a meddling outsider while stressing their allegiance to their own voters' views and to gun rights. While saying they are keeping an open mind and that they support keeping guns from criminals and people with mental disorders, some moderates are avoiding specific commitments they might regret later.

"I do not need someone from New York City to tell me how to handle crime in our state. I know that we can go after and prosecute criminals without the need to infringe upon the Second Amendment rights of law-abiding North Dakotans," Heitkamp said this week, citing the constitutional right to bear arms.

Heitkamp does not face re-election next year, but Pryor and five other Senate Democrats from Republican-leaning or closely divided states do. All six, from Southern and Western states, will face voters whose deep attachment to guns is unshakeable ? not to mention opposition from the still-potent National Rifle Association, should they vote for restrictions the NRA opposes.

"We have a politically savvy and a loyal voting bloc, and the politicians know that," said Andrew Arulanandam, spokesman for the NRA, which claims nearly 5 million paying members.

The heart of the Senate gun bill will be expanded requirements for federal background checks for gun buyers, the remaining primary proposal pushed by Obama and many Democrats since 20 first-graders and six women were shot to death in December at an elementary school in Newtown, Conn. Senate Democratic leader Harry Reid of Nevada has said there aren't enough votes to approve a ban on assault weapons, while prospects are uncertain for a prohibition on large-capacity ammunition magazines.

Today, the background checks apply only to sales by the nation's roughly 55,000 federally licensed gun dealers. Not covered are private transactions like those at gun shows and online. The Senate measure is still evolving as Sens. Chuck Schumer, D-N.Y., Joe Manchin, D-W.Va., and Mark Kirk, R-Ill., use Congress' two-week recess to negotiate for additional support in both parties.

Expanding background checks to include gun show sales got 84 percent support in an Associated Press-GfK poll earlier this year. Near-universal background checks have received similar or stronger support in other national polls.

Polls in some Southern states have been comparable. March surveys by the Quinnipiac University Polling Institute found more than 9 in 10 people in Florida and Virginia backing expanded background checks, the same margin found by an Elon University Poll in North Carolina in February.

Analysts say people support more background checks because they consider it an extension of the existing system. That doesn't translate to unvarnished support from lawmakers, in part because the small but vocal minorities who oppose broader background checks and other gun restrictions tend to be driven voters that politicians are reluctant to alienate.

"It's probably true that intense, single-issue gun voters have been more likely to turn out than folks who want common-sense gun laws," said Mark Glaze, director of Mayors Against Illegal Guns, the group that Bloomberg helps lead. Glaze, however, said he believes that voters favoring gun restrictions have become more motivated since Newtown and other recent mass shootings.

Several moderate Democrats are holding back as they assess the political landscape. They're also waiting to see exactly what the Senate will consider.

Sen. Mark Begich, D-Alaska, said Wednesday his state's voters tell him, "Don't take away our rights, our individual rights, our guns." Begich said he opposes a strict proposal requiring background checks for nearly all gun sales but will wait to see whether there is a bipartisan compromise he can support.

The problems faced by gun control supporters go beyond the challenge of winning over moderate Democrats. GOP opponents are sure to force Democrats to get 60 of the Senate's 100 votes to win, and there are only 53 Democrats plus two independents who generally support them.

Also targeted by Bloomberg's ads are 10 Republicans, including Sen. Jeff Flake of Arizona, home of ex-Rep. Gabrielle Giffords, who was severely wounded in a mass shooting; the retiring Sen. Saxby Chambliss of Georgia; and moderate Sen. Susan Collins of Maine.

In another indicator of hurdles facing gun control forces, the Senate voted 50-49 last week to require 60 votes for any legislation narrowing gun rights. The proposal lost because 60 votes in favor were required, but six Democrats voted for the proposal, offered by conservative Sen. Mike Lee, R-Utah.

"It confirms there's no such thing as an easy gun vote," said Jim Kessler, a senior vice president of the centrist Democratic group Third Way.

Underscoring the uncertainty about moderate Democrats:

?Sen. Mark Warner, D-Va., is "still holding conversations with Virginia stakeholders and sorting through issues on background checks" and proposals to ban assault weapons and high capacity ammunition magazines, spokesman Kevin Hall said.

?Pryor said of Bloomberg's ads: "I don't take gun advice from the mayor of New York City. I listen to Arkansans." Spokesman Michael Teague said Pryor opposes universal background checks but could favor expanding the requirement to gun show sales.

?Sen. Kay Hagan, D-N.C., told the Greensboro News & Record she favors expanded background checks, but said her vote would depend on the measure's details. Sen. Joe Donnelly, D-Ind., answered, "Yes," when the Fort Wayne Journal Gazette asked whether he supports gun show background checks ? prompting Bloomberg's group to remove Donnelly's name from the ad they are running in Indiana.

The gun bill also increases penalties for illegal gun sales and slightly boosts aid for school safety.

More abrupt changes like an assault weapons ban generally get slight majorities in polls. Democratic leaders decided to omit it from the Senate bill because such a provision lacks enough votes.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-28-Gun%20Control-On%20the%20Fence/id-e3e8b5712d2c47669756bf2ab198086f

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Signed contracts to buy US homes dips slightly

In this Friday, Feb. 22, 2013, photo, a sale pending announcement sits atop a for sale sign in a home's yard in Richardson, Texas. Fewer Americans signed contracts to buy homes in February, but the level stayed close to a nearly three-year high. The report suggests sales of previously occupied homes will keep rising in the coming months. (AP Photo/LM Otero)

In this Friday, Feb. 22, 2013, photo, a sale pending announcement sits atop a for sale sign in a home's yard in Richardson, Texas. Fewer Americans signed contracts to buy homes in February, but the level stayed close to a nearly three-year high. The report suggests sales of previously occupied homes will keep rising in the coming months. (AP Photo/LM Otero)

WASHINGTON (AP) ? Fewer Americans signed contracts to buy homes in February, but the level stayed close to a nearly three-year high. The report suggests sales of previously occupied homes will keep rising in the coming months.

The National Association of Realtors said Wednesday that its seasonally adjusted index for pending home sales dipped to 104.8 in February. That's down from January's reading of 105.2 ? the highest since April 2010, when a homebuyer's tax credit was boosting sales.

Signed contracts are 8.4 percent higher than a year ago.

There is generally a one- to two-month lag between a signed contract and a completed sale.

In February, completed sales of previously occupied homes rose to a seasonally adjusted pace of 4.98 million, the fastest in more than three years. The gains in both signed contracts and completed sales point to a housing recovery that is strengthening, although re-sales remain below the 5.5 million that are consistent with healthy markets.

Steady hiring and near record-low mortgage rates have encouraged more Americans to buy homes more than six years after the housing market started to collapse. More people are also moving out on their own after living with friends and relatives in the recession. That's driving a big gain in apartment construction and also pushing up rents.

Pending home sales rose 0.4 percent in the Midwest and 0.1 percent in the West last month. They fell 2.5 percent in the Northeast and 0.3 percent in the South.

One concern is that a shortage of available homes is limiting sales in many markets. More people are also starting to put their homes on the market, which could help sales in the coming months.

The Realtors' group last week said that the number of available homes for sale rose 10 percent last month, the first monthly gain since April. Even with the gain, the inventory of homes for sale was still 19 percent below a year ago.

A limited supply of homes for sale has helped drive prices higher.

U.S. home prices rose 8.1 percent for the 12 months that ended in January, according to the Standard & Poor's/Case-Shiller 20-city index. That's the fastest annual pace since June 2006. Prices rose in all 20 cities surveyed and eight markets posted double digit gains.

Stable price gains should encourage more people to buy and put their homes on the market, keeping the housing recovery going. And higher home prices make people feel wealthier, which leads consumers to spend more and drives more economic growth.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-27-Pending%20Home%20Sales/id-a40b56d00855448e894e33d732fecacb

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The first thing they do, they?ll bankrupt the divorce lawyers! (Unqualified Offerings)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/295007361?client_source=feed&format=rss

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Certain breast cancers have a trait that could be attacked by new therapies

Mar. 27, 2013 ? More than 100 women per day die from breast cancer in the United States. The odds of developing breast cancer increase for women taking hormone replacement therapy to avoid the effects of menopause. New research by University of Missouri scientist Salman Hyder may lead to treatments for breast cancers associated with taking these synthetic hormones. Hyder, along with an international team, found that hormone-therapy-related breast cancer cells have a physical feature that could be attacked by cancer therapies.

"We identified a specific cell membrane protein that blocks cell death in breast cancer cells and allows these cells to grow in response to hormone replacement therapy," said Hyder. "Others have observed an over-abundance of these proteins in a population of breast cancer cells which may explain increased risk of breast cancer in women who consume hormone replacement therapy. Therapies could be developed that would block the activity of these cell membrane proteins, which would make cancer cells more likely to die. The membrane protein is known as PGRMC1."

The proteins identified by Hyder and his colleagues were affected by progestin, one of the hormones given to women to stave off the effects of menopause. Progestin is a synthetic chemical which mimics the hormone progesterone. In hormone replacement therapy, doctors prescribe progestin along with synthetic replicas of the hormone, estrogen.

"Every progestin type that we have tested has negative effects," said Hyder. "A growing body of evidence suggests women should be wary before taking progestin. However, if women take only synthetic estrogens, such as estradiol, it leads to a higher risk of uterine cancer. Hence, the two must be taken together, but even then they seem to still increase cancer risks in post-menopausal women."

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The above story is reprinted from materials provided by University of Missouri-Columbia.

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Journal Reference:

  1. Hans Neubauer, Xiangyan Ruan, Helen Schneck, Harald Seeger, Michael A. Cahill, Yayun Liang, Benfor Mafuvadze, Salman M. Hyder, Tanja Fehm, Alfred O. Mueck. Overexpression of progesterone receptor membrane component 1. Menopause: The Journal of The North American Menopause Society, 2012; : 1 DOI: 10.1097/gme.0b013e3182755c97

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/SHkVesu6mas/130327163258.htm

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Wednesday, March 27, 2013

Developing our sense of smell

Tuesday, March 26, 2013

When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult life?as some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.

Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cells?multipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth muscle?also play a key role in building olfactory sensory neurons in the nose.

"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.

The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.

In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.

They made this discovery by studying the development of the olfactory system in zebrafish?a useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.

"A key question in developmental biology?the extent of neural-crest stem cell contribution to the olfactory system?has been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."

Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.

###

California Institute of Technology: http://www.caltech.edu

Thanks to California Institute of Technology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127460/Developing_our_sense_of_smell

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How will climate change affect the Himalayas? Scientists trek to find out.

Almost half of the world gets its water from the Himalayas and other high mountains, but little is known about how global warming will affect these sources. A team of scientists ventured to the roof of the world to investigate.?

By Tanya Lewis,?LiveScience / March 22, 2013

Rinchen Zoe plateau, Bhutan Himalaya.

David Putnam

Enlarge

The distribution of water in Asia's highest mountains and driest deserts tells an important story of climate change.

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Almost half the world's population gets its water from glacier melt and rainfall in the Himalayas and other lofty peaks, yet little is understood about how climate change will affect these water sources. Now, using sophisticated technology and old-fashioned fieldwork, scientists are looking into the past to solve this mystery.

"We're trying to understand the relationships between climate and glaciers and Earth's water resources from the perspective of Earth's paleoclimate," geologist Aaron Putnam of the Lamont Doherty Earth Observatory said in a talk at the Columbic Club in New York on March 12. He described his recent expeditions along the Silk Road, from the Tien Shan Mountains to the Taklamakan Desert to the Bhutanese Himalayas.

Tien Shan Mountains

Putnam and colleagues set out in 2010 to the Tarim Basin in Northwest China, right in the center of Asia. Within the Tien Shan Mountains, a range that extends some 1,740 miles (2,800 kilometers), the scientists studied masses of soil and rock debris built up by glaciers, called moraines, which held clues to the past climate. [Stunning Scenes: From the Himalayas to the Taklamakan Desert]

To determine the ages of the moraines, the researchers used a technique known as beryllium-10 exposure dating. Cosmic radiation constantly bombards the Earth's surface, changing the form of some of the elements, like beryllium, in rocks. Based on these changes, the scientists could determine how long the moraines had been there, which allowed researchers to reconstruct the glaciers' past positions. "We can see what the ice looked like and know exactly when the ice was there," Putnam said.

Deep in the desert

Next, Putnam and colleagues ventured to the Taklamakan Desert. New roads have made the desert accessible, "so we were able to access lands people had died trying to visit even a decade ago," Putnam said. He described the area as a parched, desolate landscape with endless expanses of sand dunes.

As the researchers trekked through the desert, they noticed silts, mud cracks, remnants of trees, even shells ? all telltale signs of water. To find out when this wet period took place, the scientists used radiocarbon dating, a technique that measures the ratio of different forms of carbon to find an object's age. The scientists also used dendrochronology, a method of determining trees' ages based on their growth rings. The results suggested the wet period occurred from the mid-1100s to the late 1800s.

Putnam and his team then traveled to the easternmost part of the desert to an enormous dry lakebed called Lop Nor. They did radiocarbon dating of shells on the lake's shoreline, finding the shells' ages matched those of the other samples from formerly wet areas. That span of time, from the 12th century to the 19th century, was a cold period in North Atlantic regions. "When it got cold in the North Atlantic, it got wet in the mid-latitude desert regions," Putnam said.

The onset of wet conditions in the Taklamakan Desert corresponds with the rise of Genghis Khan and the Mongol Empire, the largest contiguous land empire in history. The Mongols relied heavily on horses, which would have needed lots of grass to eat. Putnam and his team think the wetting of the desert allowed grasslands to expand, enabling the Mongols to spread throughout Asia. [10 Surprising Ways Weather Changed History]

Atop the Himalayas

Next, Putnam and his colleagues headed south to the Himalayas of Bhutan, an area swept by the monsoon. "We don't know how the monsoon will affect glacier behavior in the Himalayas," Putnam said, adding, "We just needed to go there and use good old-fashioned fieldwork to figure it out." The team made a six-day trek to their study site, a glacier-laden plateau.

The journey wasn't easy; it took 25 horses and mules to carry all of the supplies from the deep jungles up to the icy peaks. The team hiked over 15,400-foot-high (4,700 meters) mountain passes, home to creatures like the Himalayan blue sheep, or bharal.

Finally, the team crested Bhutan's Rinchen Zoe plateau. They ventured out onto the glaciers and took ice sample to measure the amount of melt. The scientists used the same beryllium dating method as before to determine the age of the glacial deposits, work that is currently in progress. The team had to leave before the snows came with the approaching winter.

Though the scientists haven't finished their analysis yet, it's clear that the glaciers have substantially receded over the last century, Putnam said, and this will have an impact on the many people who depend on the mountains for water.

With the current global warming trend, Putnam expects to see a northward expansion of the deserts. The insights gained on these expeditions were only possible through fieldwork, Putnam said. "In my opinion, there's no substitute for collecting fundamental data from the natural world," he said.

Follow Tanya Lewis @tanyalewis314. Follow us @livescience, Facebook?or Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/4GxoeXAOOEs/How-will-climate-change-affect-the-Himalayas-Scientists-trek-to-find-out

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New study identifies unique mechanisms of antibiotic resistance

New study identifies unique mechanisms of antibiotic resistance [ Back to EurekAlert! ] Public release date: 26-Mar-2013
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Contact: Jennifer Kritz
Jennifer.Kritz@tufts.edu
617-636-3707
Tufts University, Health Sciences Campus

BOSTON (March 26, 2013) As public health authorities across the globe grapple with the growing problem of antibiotic resistance, Tufts University School of Medicine microbiologists and colleagues have identified the unique resistance mechanisms of a clinical isolate of E. coli resistant to carbapenems. Carbapenems are a class of antibiotics used as a last resort for the treatment of disease-causing bacteria, including E. coli and Klebsiella pneumonia, which can cause serious illness and even death. Infections involving resistant strains fail to respond to antibiotic treatments, which can lead to prolonged illness and greater risk of death, as well as significant public health challenges due to increased transmission of infection. The study, published in the April issue of Antimicrobial Agents and Chemotherapy, demonstrates the lengths to which bacteria will go to become resistant to antibiotics.

Resistance to carbapenems usually emerges through the acquisition of an enzyme, carbapenemase, which destroys the antibiotic intended to treat infection. Resistance may also block entry of the drug into the E-coli bacteria. The current research, led by corresponding author Stuart Levy, M.D., Professor of Molecular Biology & Microbiology and of Medicine and Director of the Center for Adaptation Genetics & Drug Resistance at Tufts University School of Medicine, sought to determine what made this particular clinical isolate of E. coli resistant to carbapenem in the absence of carbapenemase.

"The Centers for Disease Control and Prevention has documented a significant increase in Carbapenem-resistant Enterobacteriaceae (CRE) so-called 'super bugs' that have been found to fight off even the most potent treatments," Levy said. "We knew that bacteria could resist carbapenems, but we had never before seen E. coli adapt so extensively to defeat an antibiotic. Our research shows just how far bacteria will go with mutations in order to survive."

Levy and his colleagues determined that the E. coli genetically mutated four separate times in order to resist carbapenems. Specifically, the isolate removed two membrane proteins in order to prevent antibiotics from getting into the cell. The bacteria also carried a mutation of the regulatory protein marR, which controls how bacteria react in the presence of antibiotics. The isolate further achieved resistance by increasing expression of a multidrug efflux pump. Moreover, the researchers discovered that the E. coli was expressing a new protein, called yedS, which helped the drug enter the cell, but whose expression was curtailed by the marR mutation. yedS is a normally inactive protein acquired by some E. coli that affects how the drug enters the bacterial cell. It is generally expressed in bacteria through a mutation.

According to the Centers for Disease Control and Prevention, CRE germs have increased from 1% to 4% in the United States over the last decade. Forty-two states report having identified at least one patient with one type of CRE. Approximately 18% of long-term acute care hospitals in the United States and 4% of short-stay hospitals reported at least one CRE infection in the first half of 2012.

The clinical isolate of E. coli studied by Levy and his colleagues came from the sputum of a patient at Peking Union Medical College Hospital in Beijing, China, where three of the study authors are on the faculty. Drug resistance is a particularly serious public health concern in China, antibiotics are overprescribed and used widely in the livestock and farming industries.

"The first quinolone-resistant strains of bacteria came out of China, where we see that the drugs of last resort begin being used, because the other drugs don't work after so much overuse," Levy said.

###

Additional authors of the paper are Doug Warner, Director of Undergraduate Laboratories, Boston College; Qiwen Yang, Section Director of Clinical Microbiology, Department of Clinical Laboratory, Peking Union Medical College Hospital; Valerie Duval, Research Assistant at Tufts University Center for Adaptation Genetics and Drug Resistance; Minjun Chen, Professor of Clinical Microbiology, Peking Union Medical College Hospital; and Yingchun Xu, Chair, Department of Laboratory Medicine, Peking Union Medical College Hospital.

Research reported in this publication was supported by the National Institute of Allergies and Infectious Diseases of the National Institutes of Health under award number R01AI56021.

Warner, D.M., Yang, Q., Duval, V., Chen, M., Xu, Y., Levy, S.B. (2013). Involvement of MarR and YedS in Carbapenem Resistance in a Clinical Isolate of Escherichia coli from China. Antimicrob. Agents Chemother., 57(4), 1935-1937. doi: 10.1128/AAC.02445-12.

About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences

Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.

If you are a member of the media interested in learning more about this topic, or speaking with a faculty member at the Tufts University School of Medicine or another Tufts health sciences researcher, please contact Jennifer Kritz at 617-636-3707 or Siobhan Gallagher at 617-636-6586.



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New study identifies unique mechanisms of antibiotic resistance [ Back to EurekAlert! ] Public release date: 26-Mar-2013
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Contact: Jennifer Kritz
Jennifer.Kritz@tufts.edu
617-636-3707
Tufts University, Health Sciences Campus

BOSTON (March 26, 2013) As public health authorities across the globe grapple with the growing problem of antibiotic resistance, Tufts University School of Medicine microbiologists and colleagues have identified the unique resistance mechanisms of a clinical isolate of E. coli resistant to carbapenems. Carbapenems are a class of antibiotics used as a last resort for the treatment of disease-causing bacteria, including E. coli and Klebsiella pneumonia, which can cause serious illness and even death. Infections involving resistant strains fail to respond to antibiotic treatments, which can lead to prolonged illness and greater risk of death, as well as significant public health challenges due to increased transmission of infection. The study, published in the April issue of Antimicrobial Agents and Chemotherapy, demonstrates the lengths to which bacteria will go to become resistant to antibiotics.

Resistance to carbapenems usually emerges through the acquisition of an enzyme, carbapenemase, which destroys the antibiotic intended to treat infection. Resistance may also block entry of the drug into the E-coli bacteria. The current research, led by corresponding author Stuart Levy, M.D., Professor of Molecular Biology & Microbiology and of Medicine and Director of the Center for Adaptation Genetics & Drug Resistance at Tufts University School of Medicine, sought to determine what made this particular clinical isolate of E. coli resistant to carbapenem in the absence of carbapenemase.

"The Centers for Disease Control and Prevention has documented a significant increase in Carbapenem-resistant Enterobacteriaceae (CRE) so-called 'super bugs' that have been found to fight off even the most potent treatments," Levy said. "We knew that bacteria could resist carbapenems, but we had never before seen E. coli adapt so extensively to defeat an antibiotic. Our research shows just how far bacteria will go with mutations in order to survive."

Levy and his colleagues determined that the E. coli genetically mutated four separate times in order to resist carbapenems. Specifically, the isolate removed two membrane proteins in order to prevent antibiotics from getting into the cell. The bacteria also carried a mutation of the regulatory protein marR, which controls how bacteria react in the presence of antibiotics. The isolate further achieved resistance by increasing expression of a multidrug efflux pump. Moreover, the researchers discovered that the E. coli was expressing a new protein, called yedS, which helped the drug enter the cell, but whose expression was curtailed by the marR mutation. yedS is a normally inactive protein acquired by some E. coli that affects how the drug enters the bacterial cell. It is generally expressed in bacteria through a mutation.

According to the Centers for Disease Control and Prevention, CRE germs have increased from 1% to 4% in the United States over the last decade. Forty-two states report having identified at least one patient with one type of CRE. Approximately 18% of long-term acute care hospitals in the United States and 4% of short-stay hospitals reported at least one CRE infection in the first half of 2012.

The clinical isolate of E. coli studied by Levy and his colleagues came from the sputum of a patient at Peking Union Medical College Hospital in Beijing, China, where three of the study authors are on the faculty. Drug resistance is a particularly serious public health concern in China, antibiotics are overprescribed and used widely in the livestock and farming industries.

"The first quinolone-resistant strains of bacteria came out of China, where we see that the drugs of last resort begin being used, because the other drugs don't work after so much overuse," Levy said.

###

Additional authors of the paper are Doug Warner, Director of Undergraduate Laboratories, Boston College; Qiwen Yang, Section Director of Clinical Microbiology, Department of Clinical Laboratory, Peking Union Medical College Hospital; Valerie Duval, Research Assistant at Tufts University Center for Adaptation Genetics and Drug Resistance; Minjun Chen, Professor of Clinical Microbiology, Peking Union Medical College Hospital; and Yingchun Xu, Chair, Department of Laboratory Medicine, Peking Union Medical College Hospital.

Research reported in this publication was supported by the National Institute of Allergies and Infectious Diseases of the National Institutes of Health under award number R01AI56021.

Warner, D.M., Yang, Q., Duval, V., Chen, M., Xu, Y., Levy, S.B. (2013). Involvement of MarR and YedS in Carbapenem Resistance in a Clinical Isolate of Escherichia coli from China. Antimicrob. Agents Chemother., 57(4), 1935-1937. doi: 10.1128/AAC.02445-12.

About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences

Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.

If you are a member of the media interested in learning more about this topic, or speaking with a faculty member at the Tufts University School of Medicine or another Tufts health sciences researcher, please contact Jennifer Kritz at 617-636-3707 or Siobhan Gallagher at 617-636-6586.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/tuhs-nsi032613.php

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